Saliva plays a vital role in protecting the soft and the hard tissues and in such functions as taste, mastication and deglutition. Excessive saliva can however complicate the performance of dental procedures. Chronic hypersalivation can cause psychological problems and both local and systemic disorders.
|Name||Dosage||Warnings/precautions and contraindications||Adverse effects|
Sol. Inj: 0.3- 1.2mg
Tab 0.4-1.2 mg
W/P: Avoid overdose. Increased susceptibility to toxic effects in children.
Conventional dose may precipitate acute angle closure glaucoma in susceptible patients, convert partial organic pyloric stenosis into complete obstruction, lead to urinary retention in patients with prostatic
hypertrophy, formation of viscid plugs due to increased bronchial secretions in patients with chronic lung disease.
Contraindication: Hypersensitivity to atropine or other belladona alkaloids.
|Dryness of mouth, nose, throat, skin; blurred vision, photophobia, tachycardia, palpitation, hyperthermia.|
Adults: inj range: 0.1-0.2 mg; Tab: 1-2mg
Pediatric: slon. inj. range: 4-10ug/kg upto 0.2 mg
W/P: May produce drowsiness or blurred vision; avoid operating machinery. Caution
in elderly, autonomic neuropathy, renal and hepatic disease, ulcerative colitis,
coronary heart disease, HTN.
Hypersensitivity to glycopyrrolate, acute closure glaucoma,
severe ulcerative colitis, unstable cardiovascular status in acute
hemorrhage, myasthenia gravis
|Dryness of mouth, nose, throat, skin; blurred vision, tachycardia, palpitation, loss of taste, headache.|
Adults: Cancer patients: 15-30 mg/day;
Sjogren syndrome: 5mg qid.
W/P: Caution with significant cardiovascular disease, biliary tract disease, controlled
asthma, chronic bronchitis or COPD requiring
Monitor for toxicity and dehydration. May cause renal colic.
Uncontrolled asthma, hypersensitivity to pilocarpine.
|Sweating, nausea, xerostomia, rhinitis, chills, flushing, pharyngitis, HTn, bradycardia, tachycardia|